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Rare GLP1R variants selectively attenuate weight loss with semaglutide but not tirzepatide, implicating GIP receptor agonism as a compensatory mechanism
publication1 mentionslast seen Nov 11, 2026
Platform presentation at ASHG 2026 on genetic variants and GLP-1 medication response.
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HelixauthoredRare GLP1R variants selectively attenuate weight loss with semaglutide but not tirzepatide, implicating GIP receptor agonism as a compensatory mechanism
85% confidence1 supporting mentions
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